Week 3 of the 2025 NFL season features several intriguing matchups that have potential playoff implications early on. ‘Thursday Night Football’ kicks off with the Miami Dolphins visiting the undefeated Buffalo Bills (-12.5, 49.5), where Josh Allen’s high-powered offense will test Miami’s struggling defense. Sunday’s slate includes the Los Angeles Rams visiting the Philadelphia Eagles (-3.5, 43.5) in a key NFC clash, and the Cincinnati Bengals visiting the Minnesota Vikings (-2.5, 42.5), where both teams will be turning to their backup quarterbacks. On Sunday Night Football, the Kansas City Chiefs (-5.5, 45.5) face the New York Giants, with Kansas City aiming to recover from an 0‑2 start, while Monday Night Football pits the Detroit Lions against the Baltimore Ravens (-4.5, 51.5) in a battle of top preseason Super Bowl contenders.Â
Effectively building NFL parlay picks can pay off big in your NFL betting strategy. NFL parlays come with a much greater risk than straight bets, but they also carry the potential of a much bigger reward. Before making any Week 3 NFL picks and parlays, you need to see the Week 2 NFL longshot parlay from SportsLine’s proven computer simulation model that pays out well over $18,000 on a $10 bet.Â
You can bet this NFL parlay using the latest DraftKings promo code, which offers $200 in bonus bets instantly plus over $200 off NFL Sunday Ticket:
The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks its since inception. The model went 37-17 on top-rated picks in 2024. Anybody following its NFL betting picks at sportsbooks and on betting sites could have seen strong returns.
Now that the simulation model has had a chance to digest the Week 3 NFL odds, it’s locked in its betting picks to form a 5-leg NFL parlay that could pay out well over $18,000 for a $10 bettor. You can only see the picks and full parlay by heading to SportsLine.
Top Week 3 NFL parlay picks
For Week 3, one of the model’s parlay picks is backing the Packers at the alternate line of -14.5 against the Browns, a bet that returns +163. The standard spread is Packers -7.5, but the model has spotted an opportunity to go much bigger here.Â
The Packers are projected to win 80% of the time on the money line, and the model’s winning margin is 15 points, leaving plenty of room to play alternate lines. The Packers have notched two dominant wins to open the season, beating the Lions 27-13 in Week 1 and the Commanders 27-18 in Week 2. Meanwhile, the Browns are winless at 0-2.
The Packers are led by quarterback Jordan Love, who has thrown for 480 yards and 4 touchdowns with no interceptions in the first two games of the 2025 season. In the backfield, running back Josh Jacobs has continued his strong performance from 2024, where he rushed for 1,329 yards and 15 touchdowns. Through the first two games of 2025, he has added 150 rushing yards and 2 touchdowns. On defense, linebacker Micah Parsons has made an immediate impact since joining the Packers, recording 1.5 sacks in his first two games and bolstering the team’s pass rush. See the rest of the picks in the Week 3 NFL parlay here.
New users can also check out the latest FanDuel promo code and get $300 in bonus bets instantly at FanDuel if your $5 bet wins.Â
How to make NFL parlay picks for a payout of well over $18k
The parlay also includes four additional picks from SportsLine’s computer model, including a first touchdown scorer prop bet that returns +900. You can only see the picks and the full parlay at SportsLine.
What are the top NFL picks for Week 3 that can be combined into a parlay that returns well over $18,000 on just a $10 bet? And what optimal touchdown scorer bet returns +900? Visit SportsLine now to see the top Week 3 NFL picks from SportsLine’s proven simulation model that can be combined for a parlay that pays well over $18,000, and find out.
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