Week 3 of the 2025 NFL season features a full slate of compelling matchups that could shape the early playoff picture. Sunday offers a packed schedule, including notable games like the Denver Broncos visiting the Los Angeles Chargers, the Philadelphia Eagles hosting the Los Angeles Rams, and San Francisco 49ers hosting the Arizona Cardinals. With such a loaded slate, daily Fantasy football players will need to dive deeper into NFL DFS player pool to find values for NFL DFS lineups. Should you target big name players like Saquon Barkley, Jalen Hurts, Bijan Robinson, Justin Herbert or Christian McCaffrey when making NFL DFS picks or building out you Week 3 NFL DFS strategy? Which potential daily Fantasy football sleepers should you consider for Week 3 NFL DFS lineups?
Before making any NFL DFS picks for Sunday or locking in NFL DFS lineups on sites like DraftKings and FanDuel, be sure to check out SportsLine’s advanced NFL DFS Lineup Optimizer.
The DFS Optimizer uses info from the SportsLine Advanced-Data Projection Model and DFS Professional Millionaire Mike McClure to identify top DFS picks/plays for any slate on betting apps like DraftKings and FanDuel. It simulates every game 10,000 times to help DFS players optimize and build winning DraftKings and FanDuel lineups. Optimize, export, and enter lineups confidently with injury updates, floor and ceiling player projections, and Vegas lines and picks all with one winning tool for sports betting apps.
Now, SportsLine’s NFL DFS Optimizer has turned its attention to Sunday’s 2025 NFL Week 3 schedule and just locked in its top daily Fantasy football lineups. You can only see its optimal lineups at SportsLine.
Top NFL Week 3 DFS picks for Sunday
One of the Optimizer’s top DFS value picks for Sunday is Colts running back Jonathan Taylor ($7,200 on DraftKings and $8,500 on FanDuel), who has an over/under of 90.5 rushing yards. The former Wisconsin standout has been a force early in the 2025 season. Through two weeks, he leads the league with 236 rushing yards on 43 carries, averaging 5.5 yards per carry. In Week 2, Taylor delivered a remarkable performance against the Denver Broncos, rushing for 165 yards on 25 carries and adding 50 receiving yards with a touchdown, earning AFC Offensive Player of the Week honors.
Over his six-year career, Taylor has amassed 1,271 carries for 6,249 rushing yards, 146 receptions for 1,168 receiving yards, and 57 total touchdowns. He holds multiple Colts franchise records, including most rushing yards in a single season (1,811 in 2021) and most rushing touchdowns in a single season (18 in 2021). Known for his explosive speed, Taylor reached a top speed of 22.38 mph on a 43-yard reception in Week 2, the fastest by an NFL ball carrier since 2020. See who else to pick here.
The Optimizer’s NFL DFS strategy also includes rostering Buccaneers quarterback Baker Mayfield ($6,600 on DraftKings and $7,900 on FanDuel). The former Oklahoma standout has gotten off to a fast start in 2025, throwing for 382 yards, five touchdowns, and no interceptions. In Week 2, Mayfield engineered a dramatic 20–19 comeback win for the Bucs against the Houston Texans, passing for 215 yards and two touchdowns.
Mayfield has amassed 25,214 passing yards and 176 touchdowns over his eight-year NFL career, earning two Pro Bowl selections. Known for his mobility and quick decision-making, he remains a dynamic quarterback capable of creating plays both in and outside the pocket. You can see the rest of the Optimizer’s NFL DFS picks here.
How to build Sunday Week 3 NFL DFS lineups
The NFL DFS Optimizer is also targeting multiple undervalued players who could explode for huge numbers on Sunday. Those players could be the difference between winning your tournaments and cash games or going home with nothing. You can only see who they are, and the rest of the Optimizer’s NFL DFS picks, at SportsLine.
So what is the optimal NFL DFS lineup for Sunday, and which under-the-radar NFL DFS picks offer huge value? Visit SportsLine now to see optimal NFL DFS picks, rankings, advice and stacks, all from an NFL DFS Optimizer that simulates every game 10,000 times, and find out.
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